Evidence for the association of ‘soluble’ enzymes in vivo is extensive and compelling. These associations occur in all compartments of the cell of both prokaryotes and eukaryotes. Several factors present in vivo promote these associations among enzymes whose association in vitro is often too weak to detect. Several physiological advantages of the associated enzyme complexes can be identified, most (but not all) of which are the consequence of microcompartmentation of metabolites (substrate channeling). Substrate channeling of intermediates by either a ‘direct (...) transfer’ process or ‘proximity effects’ can occur. The latter mechanism does not require the special molecular features needed for the direct transfer mechanism and may, therefore, exist in more general situations in the cell. Criticisms of these views are discussed. We argue that these criticisms have been largely answered by experiment and theory in recent years. Studies on simple systems in vitro, nevertheless, contribute important insights concerning the more complex phenomena in vivo. (shrink)

The first part of this paper deals with Mill’s influential criticism of the natural law tradition. According to Mill, this tradition is based on a mistaken conception of nature. This essay argues that Mill’s own view of nature is misconceived and that this misconception leads him to misrepresent the tradition itself. The second part deals with those modern philosophers who reject the natural law tradition but who nevertheless attempt to account for morality as being based on human nature. Certain criticisms (...) are made of their views. The chief criticism is that their views are based on an idea of nature that is no different from Mill’s. (shrink)

My title has been taken from the following passage in Wittgenstein's Philosophical Investigations:Describe the aroma of coffee—why can't it be done? Do we lack the words? And for what are words lacking?—But how do we get the idea that such a description must after all be possible? Have you ever felt the lack of such a description? Have you tried to describe the aroma and not succeeded?.

Wittgenstein's view of philosophy in the Tractatus presupposes that thought may be revealed without remainder in the use of signs. It is commonly held, however, that in the Tractatus he treated thought as logically prior to language. If this view, expressed most lucidly by Norman Malcolm, were correct, Wittgenstein would be inconsistent in holding that thought can be revealed without remainder in the use of signs. I argue that this is not correct. Thought may be prior to language in time (...) but not in logic, for non-verbal symbols must have a logical structure in common with verbal ones. A view comparable with Malcolm's holds that Wittgenstein, under the influence of Schopenhauer, is committed to some form of solipsism. I argue that neither Schopenhauer nor Wittgenstein held any version of solipsism. For both philosophers, subject and object are correlative, so that it is incoherent to affirm the existence of the one without presupposing the existence of the other. (shrink)

In recent times Wittgenstein's work in logic has had an influence on other branches of philosophy. I am thinking, in particular, of social philosophy and the philosophy of religion. In these branches, Wittgenstein's followers have made much use of his notion of a language game. It has been argued, for example, that religion forms a language game of its own, having its own standards of reason, and is therefore not subject to criticism from outside. This argument has given rise to (...) controversy, some seeing it as a subtle attempt by the religious to evade criticism. I have come myself to feel that the notion of a language game has been put to uses with which Wittgenstein himself might not have agreed, or, if he had, would have been wrong to do so. In order to explain what I mean I should like to look closely at the opening section of Peter Winch's article ‘Understanding a Primitive Society’. (shrink)

_Hume's Naturalism_ provides a clear and concise guide to the debates over whether Hume's empiricism or his 'naturalism' in the tradition of the Scottish 'Common Sense' school of philosophy gained his upper hand. This debate is central to any understanding of Hume's thought. H.O. Mounce presents a beautifully clear guide to Hume's most important works, _The Treatise on Human Nature_ and _Dialogues Concerning Natural Religion_. Accessible to anyone coming to Hume for the first time, _Hume's Naturalism_ affords a much needed (...) overview of the key concepts of empiricism, causation, scepticism, reason and morality that are essential to any understanding of Hume's philosophy. (shrink)

Book reviewed in this article:F.H. Bradley, Collected Works Volumes 1–5.

When scientists consider the interaction of science and value judgments, debates often occur. When public policy grows out of science, disagreements between scientists can become even more spirited. This paper examines the case of nutrition policy in the United States, which has been both at the interface between agriculture and medicine and the object of serious discord concerned with the strength and validity of the scientific evidence and the responsibility for action. The development of indirect intervention policies, designed to educate (...) and inform the public on diet and health, is traced as a practical demonstration of the effects of involvements of nutritional scientists of different disciplines and philosophic bents. Controversies centered mainly on the issues of diet and coronary heart disease and of diet and cancer in nutritional guidelines for Americans and the recommended dietary allowances. But the arguments turned on a complex web of values and interests as well as scientific questions. A remarkable turnaround by animal agriculture and its scientific support occurred, changing from a defensive, rightist stance to one that appears to recognize a moral responsibility to the public health. The convincing point was likely the changing market. Nutritional scientists, however, remained divided on the issue of whether a public health strategy keyed to public education should replace a strategy to identify persons of high risk and modify the risk by treatment. Our analysis suggests that the tension between libertarian and utilitarian social values of scientists is at least as important as disagreements relative to validity and strengths of the scientific evidence. (shrink)

Philosophical Investigations, EarlyView.

Rhees seems unaware that Simone Weil differed from him both in her conception of philosophy and of its relation to religion. She differed also in her view of the relation between religion and science. On her view, the aim of science is to find the laws which will allow us to apply deductive reasoning to nature. The necessities revealed had for her a religious significance. But this can be understood only given her view of the relation between God and the (...) world. On her view, the creation of the world did not involve an extension of God's power. It involved a withdrawal of his power, so that there could be an existence independent of himself. God does not interfere in the details of the world but sustains it through a network of necessities. For this reason, these necessities can serve as a sign of God. (shrink)

Wittgenstein is often thought to have undermined the view, attributed to Descartes, that the mental is in a special sense private. In fact this idea of privacyis more plausibly attributed to the empiricists than to Descartes. Nor is Descartes’s own view one that can easily be dismissed. In particular, it can serve to correct a tendency, among Wittgenstein’s followers, to treat the mental in behavioristic terms. The point is illustrated by reference to an issue in Christian theology.

This title was first published in 2001: Tolstoy's view of art is discussed in most courses in aesthetics, particularly his main text What is Art? He believed that the importance of art lies not in its purely aesthetic qualities but in its connection with life, and that art becomes decadent where this connection is lost. This view has often been misconceived and its strength overlooked. This book presents a clear exposition of Tolstoy's What is Art?, highlighting the value and importance (...) of Tolstoy's views in relation to aesthetics. Mounce considers the problems which exercised Tolstoy and explains their fundamental importance in contemporary disputes. Having viewed these problems of aesthetics as they arise in a classic work, Howard Mounce affords readers fresh insights not simply into the problems of aesthetics themselves, but also into their contemporary treatment. Students and interested readers of aesthetics and philosophy, as well as those exploring the works of Tolstoy in literature, will find this book of particular interest and will discover that reading What is Art? with attention, affords something of the excitement found in removing the grime from an oil painting - gradually from underneath there appears an authentic masterpiece. (shrink)